Echocardiography and noninvasive imaging in cardiac resynchronization therapy: results of the PROSPECT (Predictors of Response to Cardiac Resynchronization Therapy) study in perspective.

摘要

Over the past decade, cardiac resynchronization therapy (CRT) has changed the treatment of patients with end-stage, drug-refractory heart failure. Evidence of 8 large trials (including 4,017 patients) (1-8) and numerous small studies have demonstrated the benefit of CRT on heart failure symptoms, exercise capacity, and systolic left ventricular (LV) function. Various studies demonstrated reverse remodeling after CRT, with a reduction in severity of mitral regurgitation. Moreover, recent data demonstrated a reduction in heart failure hospitalization and mortality after CRT (6).