Acute Adverse Reactions of Three Intravenous lodinated Contrast Media in Computed Tomography under Routine Clinical Monitoring: lothalamate meglumine, lopromide and lohexol

摘要

Nonionic iodinated contrast media (NICM) is generally considered to have a much lower incidence of acute adverse drug reactions (aADRs) than ionic iodinated contrast media (IICM). Several studies have compared aADRs of IICM to NICM but few compared between different NICMs. There are few large local studies of adverse reactions to iodinated contrast media (ICM) in Taiwan. We undertook a retrospective study to compare the aADRs between different ICM in computed tomography (CT) under routine clinical monitoring.All consecutive patients who received intravenous contrast-enhanced CT scans using lothalamate meglumine, lopromide, or lohexol from May 2004 to February 2006 were enrolled. In total 32499 enrolled patients received either lothalamate meglumine (7520, 23.14%), lopromide (9830, 30.25%), or lohexol (15149, 46.61%). Two categories of injection rate were classified: rapid (>2 mL/sec) and slow (manual injection). Acute ADRs were classified by systemic symptoms. The statistical methods used were Fisher's exact test and Chi-squared test.