Simultaneous Determination of Di(2-ethylhexyl)phthalate,Mono(2-ethylhexyl)phthalate, and Phthalic Acid Migrating from Gamma-Ray Irradiated Polyvinyl Chloride Sheet by Liquid Chromatography-Tandem Mass Spectrometry

摘要

The aim of the present study was to establish a liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the simultaneous determination Of di(2-ethylhexyl) phthalate (DEHP), mono(2~ethylhexyl)phthalate (MEHP), and phthalic acid (PA). In the proposed method, the limits of detection of DEHP, MEHP, and PA were 5, 0.5, and 1 ng/mL, respectively, and the limits of quantification with standard solutions were 20, 2, and 5 ng/mL, respectively. Intra- and interday assays showed good accuracy and repeatability. The recoveries of DEHP, MEHP, and PA from respective extraction solvents ranged from 98.9 to 104.2% (relative standard deviation was below 10.3%). DEHP and its breakdown products migrating from gamma-ray irradiated polyvinyl chloride (PVC) sheets were determined simultaneously since DEHP is easily eluted from PVC medical devices.