Serotonin 1A receptors in the action of antipsychotic drugs: Comment on 'Measurement of the serotonin 1A receptor availability in patients with schizophrenia during treatment with the antipsychotic medication ziprasidone' by Frankle et al. 2011; 25(6): 734-743

摘要

In a recent issue of the Journal, Frankle et al. (2011) report excellent data on the effect of ziprasidone, an atypical antipsy-chotic drug acting as a serotonin (5-HT)_(1A) receptor agonist, on 5-HT_(1A) receptor binding by using [~(11)C] WAY 100635, a PET radi-otracer labeling these receptors, in patients with schizophrenia. Treatment with ziprasidone for 3 weeks did not affect 5-HT,_(1A) binding with ziprasidone in the prefrontal cortex (PFC), including orbitofrontal cortex (OFC). On the other hand, 5-HT_(1A) binding in PFC regions, especially OFC, while taking ziprasidone, was inversely correlated with improvements in negative symptoms (Frankle et al., 2011). The latter finding is consistent with a role for 5-HT_(1A) receptors in the ability of the drug to ameliorate negative symptoms