Effects of hydrated forms of C-60 fullerene on amyloid beta-peptide fibrillization in vitro and performance of the cognitive task

摘要

It has been shown for the first time by transmission electron microscopy that the hydrated fullerene C-60 inhibited the fibrillization of amyloid-beta(25-35) peptide. The fullerene affected the amyloid-beta(25-35) assembly, manifesting its anti-amyloidogenic capacity. Our in vivo investigations demonstrated also that a single intracerebroventricular injection of the C-60 hydrated fullerene at a dose of 7.2 nmol/ventricle significantly improved the performance of the cognitive task in control rats. The intracerebroventricular injection of the C-60 hydrated fullerene (3.6 nmol/ventricle) prevented the impairment of performance of the cognitive task induced by amyloid-beta(25-35) (22.5 nmol/ventricle). The results obtained may be useful in the development of therapy of Alzheimer's disease.