Minor structural modifications convert a selective PPARalpha agonist into a potent, highly selective PPARdelta agonist.

摘要

We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor delta (PPARdelta) based on a lead structure from our PPARalpha program. Compound 33 showed good pharmacokinetics.