PC.02. A novel method to derive central aortic systolic pressure (CASP) from the radial artery pressure waveform: validation with data from the CAFE study

摘要

Objective: Central systolic pressure (CJ3P) may beestimated directly from the radial artery pressure waveform (RAPWF) by identifying an inflectionpoint on the systolic down-stroke. Identification of this inflection point can however, be problematic. This study describes and evaluates a novel methodfor identifying C_SP from RAPWFs which is independent of the need to identify an inflection point or the use of a generalised transfer function (GTF).Methods: We used an u-point forward moving average method [n -1/4 tonometer sampling rate) to derive the maximum pressure value from RAPWF data arrays, which we hypothesised would equate to C_SP and have termed CASP. We used 5366 RAPWFs obtained using applanation tonometry from the Leicester cohort of the CAFE study to compare calculated values of CASP with values for C_SP derived by conventional RAPWF GTF transformation (SphygmoCor~R).