Comparison of intravenous urapidil and oral captopril in patients with hypertensive urgencies.

摘要

In a prospective, double-blinded, double-dummy, randomized study, 69 patients with a hypertensive urgency (systolic blood pressure (SBP) > 220 mm Hg and/or diastolic blood pressure (DBP) > 110 mm Hg) received either captopril or urapidil to reduce of SBP < 180 mm Hg and DBP < 90 mm Hg and blood pressure was measured by an ambulatory blood pressure unit for at least 12 h. The area-under-the-curve (AUC) of SBP and DBP was 163 (20)/85 (12) mm Hg for the urapidil group and 159 (17)/88 (9) mm Hg for the captopril group (P-values 0.38/0.40)and the AUC above 180/90 mm Hg was 4.6 (4.9)/4.7 (5.7) mm Hg versus 2.7 (5.1)/5.3 (6.3) mm Hg (P = 0.12/P = 0.42) demonstrating that intravenous urapidil may be also an useful drug in the treatment of hypertensive urgencies.