The synthesis of some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5- methyl-1H-1,2,3-triazole-4-carboxamide

摘要

Some new (S)-1-aryl-N-(1-hydroxy-3-phenylpropan-2-yl)-5-methyl-1 H-1,2,3-triazole-4-carboxamides 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 4i, 4j have been synthesized and established by ~1H and ~(13)C NMR, IR, MS spectra, CHN analyses, and x-ray diffraction crystallography. The molecular conformation and packing is stabilized by interactions of intermolecular H-bond O2'-H2'?O1, O2-H2?O1' and intramolecular H-bond N4'-H4'N?N3', N4'-H4'N?O2', N4-H4N?N3, N4-H4N?O2. The two rings of five numbers were formed by H-bond in a molecular.