Synthesis and spectral determination of new derivatives of 1-[(p-substituted)phenyl]-3a-[(o- and p-substituted)phenyl]-5-chloro-9-methylthio-10,3a-dihydro-[1,2,4]-oxadiazolo[2,3-b][1,4]benzodiazepines

摘要

A new synthesis to obtain eight novel derivatives of 1-[(p-substituted)phenyl]-3a-[(o- and p-substituted)phenyl]-5-chloi-o-9-methylthio-10,3a-dihydro-[1,2,4]-oxadiazolo[2,3-b][1,4]benzodiazepines with possible biological and pharmacological activity as anxiolytics, hypnotics, anticonvulsants in the central nervous system. The final products were obtained by condensation between 2-methylthio-5-[(o-; p-substituted)phenyl]-3H-7-chloro-[1,4]benzodiazepine with benzonitrile oxide generated in situ from benzohydroxamoyl chloride in triethylamine. The structure of all products was corroborated by ir, H-1-nmr, C-13-nmr, with experiments bidimensional and ms in low and high resolution.