A solvent-free protocol for one pot conversion of Baylis Hillman acetates to pyridopyrimidinones

摘要

A facile one pot transformation of Baylis Hillman acetates to pyrido[1,2-a]pyrimidin-2-ones by reaction with 2-amino pyridine in a total solvent-free protocol is illustrated. The 3-substituted-2H-pyrido[1,2-a] pyrimidin-2-ones are obtained in pure form without involving any purification technique or solvent.