Synthesis and bioactivity of xyridin A and B, metabolites from Xyris indica

摘要

A facile synthesis of the title isocoumarins isolated from Xyris indica was accomplished. Condensation of butanoyl chloride and 2-oxo-butanoyl chloride with 3,4-methylenedioxyhomophthalic acid afforded xyridin A and xyridin B respectively. Xyridin A was saponified to the corresponding keto acid which on reduction furnished the (+/-)-3,4-dihydro-6,7-methylenedioxy-3-propylisocoumarin. All of the synthesized compounds were examined in vitro for antibacterial and antifungal activities. [References: 25]