Facile Synthesis of Some Novel Tetrasubstituted 2,4-Diaminopyrimidine Derivatives in Aqueous Glucose Solution as a Fully Green Medium and Promoter

摘要

A novel environmentally benign method toward the synthesis of some novel tetrasubstituted 2,4-diaminopyrimidine derivatives using an aqueous glucose-mediated one-pot three-component reaction of malononitrile with various benzaldehyde and amidine derivatives is reported. Some pyrimidine derivatives possessing a-amino acid moiety were synthesized by the present protocol for the first time. This protocol offers advantages including facile reaction conditions, using naturally occurring glucose as promoter and water as solvent, simple work-up, relatively short reaction times, and high yields of the products.