SYNTHESIS OF 3-AMINORHODANINE DERIVATIVES AS ALDOSE REDUCTASE INHIBITORS

摘要

A number of 5-condensated 3-acylaminorhodanines 3 was prepared as potential inhibitors of the aldose reductase by acylation of the amino group of 3-aminorhodanine 1 and subsequent condensation of the 5-methylene function with appropriate aldehydes. Some of these compounds displayed interesting activity. [References: 10]