Novel 1,3,4-Oxadiazole Derivatives of Dihydropyrimidinones: Synthesis, Anti-Inflammatory, Anthelmintic, and Antibacterial Activity Evaluation

摘要

The present study depicts synthesis of a series of some novel 5-(5-(aryl)-1,3,4-oxadiazol-2-yl)-3,4-dihydro-6-methyl-4-styrylpyrimidin-2(1H)-one derivatives. All the newly synthesized compounds were characterized by FTIR, H-1 NMR, C-13 NMR, mass spectrometry, and elemental analysis. The compounds were evaluated for their in vivo anti-inflammatory activity by the carrageenan-induced rat paw edema method. The compounds were also screened for their anthelmintic activity on Indian earthworms and antibacterial activity against some gram positive and gram negative strains of bacteria. This pharmacological activity evaluation revealed that, among all the compounds screened, compounds 4b and 4c were found to have promising anti-inflammatory activity. Interestingly, compounds 4b, 4c, and 4i exhibited appreciable anthelmintic property, while compounds 4c, 4g, and 4h showed leading antibacterial activity against the selected pathogenic strains of bacteria.