首页> 外文期刊>Digestive and liver disease: official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver >The development of the neural crest is orchestrated by a complex interplay between intercellular signalling molecules and transcription factors. Here, we demonstrate a direct interaction between two such factors, the paired-type transcription factor Pax3 and the secretory glycoprotein Wntl. We found that the Wntl promoter can be regulated by Pax3 in a dose-dependent manner. Sequence analysis predicted a conserved binding site for Pax3 within the Wntl promoter region. Deletion or mutation of this
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The development of the neural crest is orchestrated by a complex interplay between intercellular signalling molecules and transcription factors. Here, we demonstrate a direct interaction between two such factors, the paired-type transcription factor Pax3 and the secretory glycoprotein Wntl. We found that the Wntl promoter can be regulated by Pax3 in a dose-dependent manner. Sequence analysis predicted a conserved binding site for Pax3 within the Wntl promoter region. Deletion or mutation of this

机译:神经c的发育是由细胞间信号分子和转录因子之间的复杂相互作用来协调的。在这里,我们证明了两个这样的因素之间的直接相互作用,成对的转录因子Pax3和分泌型糖蛋白Wnt1。我们发现Wnt1启动子可以由Pax3调节,呈剂量依赖性。序列分析预测了Wnt1启动子区域内Pax3的保守结合位点。删除或变异

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