α-Chymotrypsin inhibition studies on the lignans from Vitex negundo Linn

摘要

The lignans (1-8) isolated from the roots of Vitex negundo Linn. were screened against the serine proteases α-chymotrypsin, thrombin and prolyl endopeptidase. Compounds 3 and 4 were found to be active only against α-chymotrypsin and were noncompetitive and competitive inhibitors of the enzyme, respectively. Ki values were found to be in the range 31.75-47.11 μM.