Construction and properties of drug molecules modifying octamolybdate hybrid compounds

摘要

By introducing antibacterial drug pipemidic acid into octamolybdates, two new compounds, (HPPA)_4 [Mo_8O_(26)] 2H_2O (1) and [Ni_2(PPA)_2(H_2O)_n] [Mo_8O_(26)] 3H_2O (2) (PPA = 8-ethyl-5,8-dihydro-5-oxo-2-(l-piperazinyl)pyrido(2,3-d)pyrimidine-6-carboxylic acid), have been synthesized and characterized by physical methods. Single-crystal X-ray analysis reveal that 1 and 2 crystallize in the triclinic system, space group P-1, in which supramolecular interactions play vital roles in stabilizing the structure of 1 and 2. The results of their antitumor activities in vitro show that the compounds exhibit good anti-SGC7901 and anti-SMMC7721 activities, which indicates that the antitumor activities of Polyoxometalates can be modulated by the surface modification with drugs.