Unique endoscopic findings of colitis-associated colorectal cancer in a patient with ulcerative colitis and Lynch syndrome.

摘要

Dear Sir, A 28-year-old woman with coexistent ulcerative colitis (UC) and systemic lupus erythematosus had been treated with prednisolone and salazosulfapyridine. She underwent colonos-copy to evaluate her UC. Endoscopic examination revealed severe colonic inflammation with deep ulcers in the rectum and mild inflammation in the sigmoid colon. Moreover, colonic polyps were observed throughout the entire colon. A semipedunculated polyp (0-lsp) with a central depression, whose endoscopic findings mimicked an inflammatory polyp, was observed at the hepatic flexure (Fig. 1A). Histologic findings of biopsy specimens obtained from this polyp showed signet ring cell carcinoma with cryptal distortion and lymphoid aggregation, suggesting chronic inflammation (Fig. 1B). She was therefore diagnosed with colitis-associated colorectal cancer (CAC) related to UC and underwent a total proctocolectomy.