Prostate Cancer Molecular Background: The IGF-lEc Story

摘要

Background: Recently, a number of genetic aberrations have been associated to prostate cancer, these can either cause prostate cancer directly by affecting mechanisms central to the survival of the prostatic cell or indirectly by making the cell more sensitive to endocrine or paracrine stimuli. The mature IGF-1 is one of the most common factors involved in the development of prostate cancer. Its mode of action is exerted through the IGF-1R. It induces inhibition of apoptosis, thus promoting survival, and cellular proliferation.