Micro wave-Assisted Combinatorial Synthesis of Polysubstituent Imidazo[1,2-a]quinoline,Pyrimido[1,2-a]quinoline and Quinolino[1,2-a]quinazoline Derivatives

摘要

A series of unusual fused heterocyclic compound derivatives,consisting of a pyridine and a imidazole or pyrimidine core,with a bridgehead nitrogen,were successfully synthesized by a microwave-assisted,three-component domino reaction of aldehydes,enaminones,and malononnitrile.In this one-pot reaction,up to five new bonds were formed accompanied by generating the lactam group.This method has the advantages of short synthetic route,operational simplicity,increased safety for small-scale high-speed synthesis,and minimal environment impact.