Hartwig-Buchwald Amination on Solid Supports:a Novel Access to a Diverse Set of 1H-Benzotriazoles

摘要

Hartwig-Buchwald amination reactions of bromo-and chloroarenes were performed on solid supports with triazene-linked arenes.Immobilized 2-haloarenes were treated with diverse primary amines and anilines at 100°C under palladium catalysis to yield N-substituted 2-aminoarenes.The latter were alternatively formed through reaction of bromo-and chloroarenes with immobilized primary 2-aminobenzenes.Subsequent acidic cleavage furnished 1H-benzotriazoles in high purities.The two described routes allow a broad range of the substitution pattern of N-substituted 1H-benzotriazoles.