Microwave-Assisted Solution-Phase Parallel Synthesis of 2,4,6-Trisubstituted Pyrimidines

摘要

2,4,6-Trisubstituted pyrimidines have been shown to possess diversely biological activities.As examples,compound 1 shows in vitro antimalarial activity against Plas-modium falciparum,with an MIC value of 0.25 mu g/mL.Compound 2 is a selective adenosine A_1 receptor antagonist with high A_1 affinity (K_i = 4 nM) and selectivity.Compound 3 is a phosphotidylinositol 3 kinase inhibitor and can be used for the treatment of cancer.