Synthesis of beta-amino-alpha-ferrocenyl alcohols

摘要

beta-Amino-alpha-ferrocenyl alcohols [FcC(OH)(R)CH2NH2] (R = Me, Et, Pr-n, Pr-i, Ph, p-MeOC6H4, O-CIC6H4, M-CIC6H4, P-CIC6H4, Fc; Fc = C5H4FeC5H5) were prepared by the reduction of cyanohydrin trimethylsilyl ethers of acylferrocenes with lithium aluminum hydride. All new compounds were characterised by elemental analysis, IR and H-1 NMR spectroscopies. The X-ray crystal structure of beta-amino-alpha,alpha-diferrocenylethanol shows that it has a polymeric chain structure with hydrogen bonding interactions between the OH proton and the N of NH2.