Synthesis of an Epoxide Carbonylation Catalyst:Exploration of Contemporary Chemistry for Advanced Undergraduates

摘要

Motivation for the development of this experiment was twofold.One aspect was the desire,affirmed by the ACS,for undergraduate chemistry majors to encounter air-free synthetic techniques during the course of their studies.The other was a need to engage students' interest by involving them in current chemistry,giving them access to reactions whose stories are still developing.We have recently introduced a class of highly active,well-defined compounds for the catalytic carbonylation of epoxides and aziridines to beta-lactones and beta-lactams,respectively.