Combination of EGFR signaling pathway inhibitors and prevention of resistance

摘要

Epidermal growth factor receptor (EGFR) is a protein tyrosine kinase that plays a crucial role in signal transduction pathways that regulate key cellular functions such as survival and proliferation. Since its discovery in 1984, clinical studies have correlated EGFR overexpression with increased oncogenicity, metastatic potential, cell proliferation, apoptosis, angiogenesis and decreased patient survival. Amongst recent discoveries in molecularly targeted cancer therapies, applications centered on EGFR and its signaling pathway are currendy the most promising and the most advanced at the clinical level.