Inclusion complexation between baicalein and -cyclodextrin and the influence of -cyclodextrin on the binding of baicalein with DNA: a spectroscopic approach

摘要

This work deals with the commonly studied cyclic oligosaccharide and gains importance as it is entered on a drug delivering carbohydrate and provides insight into the oligosaccharide complex-biomolecular interaction. The binding of a flavone, baicalein, to -cyclodextrin and calf thymus DNA is studied. The binding of baicalein to calf thymus DNA in the presence of -cyclodextrin is analysed using the UV-vis absorption and fluorescence spectroscopy. The mode of binding and structure of the baicalein--cyclodextrin complex are reported. The role of the structure and the stoichiometry of the inclusion complex of baicalein--cyclodextrin in its influence on DNA binding are analysed.Highlights center dot This paper deals with the binding of a flavone, baicalein to -cyclodextrin and/or DNA.center dot The inclusion complexation between baicalein and -cyclodextrin is analysed.center dot The stoichiometry and the binding strength of the inclusion complex is reported.center dot The role of -cyclodextrin in tuning the binding of baicalein to DNA is emphasized.center dot Spectroscopic and docking analysis are used to articulate the results.