The radiosensitization effect of 2-deoxy-D-glucose on human glioma cells.

摘要

2-deoxygIucose (2-DG), a glucose analogue, blocks glycolysis, inhibits ATP generation interferes with protein glycosylation, histone regulation, and has been tested in rnultinU preclinical studies as a potential anticancer. Few studies found that 2-DG, lowers intra cellular ATP levels significantly below 15%, and, as a consequence, effect cell death Several cell culture studies have highlighted the higher rates of glucose utilization and lactate production in tumor cells5'6 and thus, it is not surprising that, in cancer models glucose deprivation is known to cause cytotoxicity in vitro and in vivo by activating multiple signal transduction pathways that are associated with angiogenesis and expression of cellular oncogenes. Evidences suggest that 2-DG causes oxidative stress-mediated cell death in tumor cells by creating a glucose deprivation effect. Both in vitro and in vivo tumor models suggest that 2-DG enhances radiosensitization effect; however, the exact mechanism of the radiosensitization of 2-DGis not fully established.