Pantoprazole-Na Release from Poly(acrylamide-co-crotonic acid)and Poly(acrylic acid-co-crotonic acid)Hydrogels

摘要

Poly(acrylamide-co-crotonic acid)(PAAmCA),poly(acrylic acid-co-crotonic acid)(PAACA),PAA and PAAm hydrogels were prepared by free radical polymerization and ethylene glycol dimethacrylate(EGDMA)as a cross-linker.The variations of swelling values(%)with time,temperature,and pH were determined for four types of hydrogels.The PAACA hydrogel was swollen 2300% at pH=7.4 and 37°C.The drug release from pantoprazole-Na loaded PAACA and PAAmCA hydrogels was followed at pH=7.4,37°C for 30 h.The release from PAACA hydrogel was faster than that from PAAmCA hydrogel;therapeutic levels for both hydrogels are obtained within 1 hour.Non-Fickian diffusion was determined for both hydrogels.