首页> 外文期刊>Journal of Bioactive and Compatible Polymers >Extracellular Matrix Components as Modulators of Adult Stem Cell Differentiation in an Adipose System
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Extracellular Matrix Components as Modulators of Adult Stem Cell Differentiation in an Adipose System

机译:细胞外基质成分作为脂肪系统中成人干细胞分化的调节剂

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摘要

The viability of a cell-based device may be controlled post-implantation by managing the level of cellular differentiation.Cellular adhesion to extracellular matrix (ECM) proteins is fundamentally linked to tissue development,maintenance of tissue organization,and many pathological conditions.Cellular interaction with ECM regulates the proliferation and differentiation of cells.This study investigates the efficacy of ECM components (laminin and collagen) in modulating the differentiation of adult mouse bone marrow stem cells (D1) to adipocytes.This study should assist in the development of clinically viable soft-tissue implants.
机译:植入后可通过管理细胞分化水平来控制基于细胞的设备的生存能力。细胞对细胞外基质(ECM)蛋白的粘附力与组织发育,组织组织的维持以及许多病理状况有着根本的联系。 ECM调节细胞增殖和分化。本研究研究ECM成分(层粘蛋白和胶原蛋白)调节成年小鼠骨髓干细胞(D1)向脂肪细胞分化的功效。该研究应有助于临床上可行的发展软组织植入物。

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