Metabolism of Metamitron in Goat Following a Single Oral Administration of a Nontoxic Dose Level: A Continued Study.

摘要

Disposition kinetic behavior and metabolism studies of metamitron and its metabolite in terms of the parent compound were carried out in black Bengal goats after a single oral administration of a nontoxic oral dose at 30 mg kg(-)(1) of body weight. Metamitron was detected in the blood sample at 5 min (2.23 +/- 0.04 mug mL(-)(1)), maximum at 1 h (3.43 +/- 0.02 mug mL(-)(1)) and minimum at 12 h (0.41 +/- 0.01 mug mL(-)(1)), after a single oral administration. Metabolite [3-methyl-6-phenyl-1,2,4-triazin-5(4H)-one] in terms of the parent compound was detected in the blood sample at 5 min (0.47 +/- 0.006 mug mL(-)(1)), maximum at 6 h (5.12 +/- 0.02 mug mL(-)(1)) and minimum at 96 h (1.06 +/- 0.016 mug mL(-)(1)), after a single oral administration. The t(1/2)(K)() and Cl(B) values of metamitron were 3.63 +/- 0.05 h and 1.36 +/- 0.016 L kg(-)(1) h(-)(1), respectively, whereas the t(1/2)(K)()(m) and Cl(B)(m) values of the metabolite were 38.15 +/- 0.37 h and 0.091 +/- 0.001 L kg(-)(1) h(-)(1), respectively, which suggested long persistence of the metabolite in blood and tissues of goat. Metamitron was excreted through feces and urine for up to 48 and 72 h, whereas the metabolite was excreted for up to 168 and 144 h, respectively. Metabolite alone contributed to 96 and 67% of combined recovery percentage of metamitron and metabolite against the administered dose in feces and urine of goat, respectively. All of the goat tissues except lung, adrenal gland, ovary, testis, and mammary gland retained the metabolite residue for up to 6 days after administration.