A person who feels sad all the time, has unexplained crying'spells, or loses interest in usual activities may have major depression, a serious medical illness that should be distinguished from normal temporary feelings of sadness after a loss, such as the death of a relative or friend. The May 19, 2Q10, issue of JAMA is a theme issue on mental health that includes several articles about depression. This Patient Page is based on one previously published in the November 12, 2008, issue of JAMA.
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