Functional transplantation of salivary gland cells differentiated from mouse early ES cells in vitro

摘要

This study examined methods of differentiation from stem cells into salivary gland cells with only biomaterials, i.e., the cell source was mouse-derived early embryonic stem (ES) (mEES-6) cells, with human salivary gland-derived fibroblasts (hSG-fibro) used as an inducer. The purpose was to investigate whether mEES-6 cells can be differentiated into salivary gland cells and if those cells are transplantable in vivo. The submandibular glands of 8-week-old female SCID/Jcl mice were used.