The Phosphodiesterase 10 Positron Emission Tomography Tracer, [F-18]MNI-659, as a Novel Biomarker for Early Huntington Disease

摘要

IMPORTANCE In Huntington disease (HD) striatal neuron loss precedes and predicts motor signs or symptoms. Current imaging biomarkers lack adequate sensitivity for assessing the early stages of HD. Developing an imaging biomarker for HD spanning the time of onset of motor signs remains a major unmet research need. Intracellular proteins whose expression is altered by the mutant huntingtin protein may be superior markers for early HD stages.