RECENT DISCLOSURES OF CLINICAL CANDIDATES HIGHLIGHTS FROM THE SOCIETY OF MEDICINES RESEARCH SYMPOSIUM, HELD DECEMBER 4, 2014-NATIONAL HEART & LUNG INSTITUTE, LONDON, UK

摘要

This symposium featured an international line-up of speakers presenting on the discovery and clinical development of novel therapeutic agents. The program included the Society of Medicines Research (SMR) Award Lecture, given by Dr. Betty Chang from Pharmacyclics on the discovery and development of the marketed drug ibrutinib, as well as talks, several representing first U.K. disclosures, on Toll-like receptor 7 (TLR7) agonists, Na(v)1.7 modulators, inhibitors of Clostridium difficile, Mdm2 inhibitors, muscarinic M 1 receptor agonists and beta-secretase 1 (BACE1) inhibitors. The meeting was held at the National Heart and Lung institute, Kensington, London, U.K. and was organized by the authors of this report.