To study physical compatibility between dibasic calcium phosphate and cohesive actives using powder rheometer and thermal methods

摘要

Aim: An attempt is made to provide better understanding of the compatibility aspect of excipients with different properties of active pharmaceutical ingredient (API) using various rheological, thermal and morphological studies conducted on binary mixtures of Dibasic Calcium Phosphate anhydrous (DCP-A) and Dibasic Calcium Phosphate dihydrate (DCP-D) forms with cohesive API's (Acetaminophen and Aspirin).