Studies on the Reactions of 4-Ethoxycarbonyl-5-phenyl-2,3-dihydro-2,3-furandione with Some NH Nucleophiles

摘要

4-Ethoxycarbonyl-5-phenyl-2,3-dihydro-2,3-furandione 1 was reacted with o-phenylenediamine.substituted ureas and methylcarbamate or acetamide to give quinoxaline 2,pyrimidine 3 and benzoylmalonic acid 4 derivatives,respectively.Benzoylmalonic acid derivative 4a was converted into a new oxozinedione derivative,5,by refluxing its solution in xylene containing a catalytic amount of p-toluene sulfonic acid.In addition,triphenylpyrazole carboxylic acid derivative 6 was obtained from the reaction of 4a with diphenylhydrazine.