A Convenient Synthesis of 3,6-Disubstituted-l,4-Dihydro-[l,2,4,5]Tetrazines and Preparation of New Acetic Acid Derivatives Containing 5-Oxo-4-Phenylamino-4,5-Dihydro- [1,2,4] Triazole

摘要

A series of compounds 8a-e,was synthesized by condensation of compounds 7a-e with ethyl bromoac-etate.The treatment of compounds 8a-e with hydrazine hydrate afforded the corresponding hydrazide derivatives (9a-e).Subsequently,compounds 9a-e were converted to alkylidene hydrazides (lOa-e).Moreover,upon heating in the presence of carboxylic acids,compounds 9a-e unexpectedly gave 1,4-dihydro-[1.2,4,5]tetrazine derivatives (lla-e).