Patients with aortic valve stenosis and Type 2 diabetes have similar coronary flow reserve and aortic distensibility compared with non-diabetic patients with aortic valve stenosis.

摘要

Macrovascular coronary artery disease (CAD) is the major cause of morbidity and mortality in patients with Type 2 diabetes mellitus (DM) . It has been demonstrated that coronary flow reserve (CFR) as a characteristic of coronary microcirculation, and aortic distensibility are impaired in Type 2 DM patients . Furthermore, patients with Type 2 DM and CAD have similar CFR compared with non-diabetic patients with CAD . In patients with significant aortic valve stenosis (AS) and a normal coronary angiogram, these functional characteristics (CFR and aortic distensibility) are reduced due to left ventricular hypertrophy, endothelial dysfunction, aorto-coronary haemodynamic relationship, reduced perfusion of the aorta, etc. . The CFR of AS patients with and without significant CAD is similar and unsuitable for prediction or differentiation of these patient populations . Most previous studies have focused on the effect of Type 2 DM in patients without valvular disease, whereas the aim of the present study was to assess the influence of Type 2 DM on coronary microcirculation and aortic distensibility in AS patients.