CRISPRa-mediated overexpression of the voltage-gated channels Kv1.1 and Nav1.1 as a new therapeutic strategy to restore excitation/inhibition balance in epileptic neuronal circuits

Di Berardino C.; Colasante G.; Lignani G.; Massimino L.; Sacchetti S.; Zaghi M.; Benfenati F.; Kullmann D.; Broccoli V.

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CRISPRa-mediated overexpression of the voltage-gated channels Kv1.1 and Nav1.1 as a new therapeutic strategy to restore excitation/inhibition balance in epileptic neuronal circuits

机译：CRISPRa介导的电压门控通道Kv1.1和Nav1.1的过表达作为恢复癫痫神经元回路中兴奋/抑制平衡的新治疗策略

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《Human gene therapy》 |2016年第11期|共1页
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Di Berardino C.; Colasante G.; Lignani G.; Massimino L.; Sacchetti S.; Zaghi M.; Benfenati F.; Kullmann D.; Broccoli V.;
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正文语种 eng
中图分类治疗学;
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1. CRISPRa-mediated overexpression of the voltage-gated channels Kv1.1 and Nav1.1 as a new therapeutic strategy to restore excitation/inhibition balance in epileptic neuronal circuits [J] . Di Berardino C., Colasante G., Lignani G., Human gene therapy . 2016,第11期

机译：CRISPRa介导的电压门控通道Kv1.1和Nav1.1的过表达作为恢复癫痫神经元回路中兴奋/抑制平衡的新治疗策略
2. Spontaneuous seizures in Kcna1-null mice lacking voltage-gated Kv1.1 channels activate Fos expression in select limbic circuits [J] . Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2015,第1期

机译：缺乏电压门控Kv1.1通道的Kcna1无效小鼠的自发性癫痫发作激活了特定边缘电路中的Fos表达
3. Voltage-gated sodium channel Nav1.1, Nav1.3 and beta1 subunit were up-regulated in the hippocampus of spontaneously epileptic rat. [J] . Guo F, Yu N, Cai JQ, Brain research bulletin . 2008,第1期

机译：电压门控钠通道Nav1.1，Nav1.3和beta1亚基在自发癫痫大鼠海马中上调。
4. IRREGULAR FIRING IN CORTICAL CIRCUITS WITH INHIBITION/EXCITATION BALANCE [C] . C. van Vreeswijk, H. Sompolinsky Computational Neuroscience Conference . 1997

机译：用抑制/激发平衡的皮质电路中的不规则射击
5. Effects of acidosis on neuronal voltage-gated sodium channels: Nav1.1 and Nav1.3 [O] . Mohammad-Reza Ghovanloo, Colin H. Peters, Peter C. Ruben 2018

机译：酸中毒对神经元电压门控钠通道Nav1.1和Nav1.3的影响
6. Spontaneous seizures in Kcna1 -null mice lacking voltage-gated Kv1.1 channels activate Fos expression in select limbic circuits [O] . Nicole M. Gautier, Edward Glasscock 2015

机译：KCNA1 -Null小鼠中的自发癫痫发作缺乏电压门控KV1.1通道激活FOS在选择肢体电路中的FOS表达式

CRISPRa-mediated overexpression of the voltage-gated channels Kv1.1 and Nav1.1 as a new therapeutic strategy to restore excitation/inhibition balance in epileptic neuronal circuits

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