Cycloaspeptide A and Pseurotin A from the Endophytic Fungus Penicillium janczewskii

摘要

Penicillium janczewskii K. M. Zalessky was isolated as an endophytic fungus from the phloem of the Chilean gymnosperm Prumnopitys andina. When grown in liquid yeast extract-malt extract-glucose broth, the fungus produced two main secondary metabolites. The com-pounds were for the first time isolated from this species and identified by spectroscopic methods as pseurotin A and cycloaspeptide A. This is the first report on the production of cyclic peptides by endophytic fungi from Chilean gymnosperms. Pseurotin A and cycloaspep-tide A presented low cytotoxicity towards human lung fibroblasts with IC_(50)≥ 1000 μM. Pseurotin A showed a moderate effect against the phytopathogenic bacteria Erwinia carotovora and Pseudomonas syringae, with IC_(50) values of 220 and 112 μg ml~(-1), respectively.