4-tert-butoxy-1-ethoxy-1,3-bis(trimethylsilyloxy)-1,3-butadiene. A new diene and its application to the synthesis of γ-alkylidenetetronic acids

摘要

A new approach to γ-alkylidenetetronic acids is reported which is based on Me_3SiOTf-catalyzed [3+2] cyclization of 4-tert-butoxy-1,3- bis(trimethylsilyloxy)-1,3-butadiene with oxalyl chloride, orthogonal protection of the α-hydroxy group by benzylation and subsequent deprotection of the β-hydroxy group.