Combination therapy of angiotensin receptor blocker with statin or thiazolidinediones as promising therapeutic strategy for metabolic syndrome and atherosclerosis.

摘要

Hypertension, insulin resistance/type 2 diabetes and hypercholesterolemia are closely associated with each other, and they all cause vascular endothelial dysfunction, develop atherosclerosis and consequently increase cardiovascular morbidity and mortality.1 Very importantly, there is a strong synergy among hypertension, type 2 diabetes, and hypercholesterolemia in terms of the risk factors for the development of cardiovascular diseases. The frequent association of these diseases aggravates the process of vascular endothelial dysfunction and atherosclerosis in patients with these comorbid conditions.