Tocilizumab added to conventional therapy reverses both the cytokine profile and CD8+Granzyme+ T-cells/NK cells expansion in refractory hemophagocytic lymphohistiocytosis

Faguer Stanislas; Vergez Francois; Peres Michael; Ferrandiz Ines; Casemayou Audrey; Belliere Julie; Cointault Olivier; Lavayssiere Laurence; Nogier Marie-Beatrice; Prevot Gregoire; Huart Antoine; Recher Christian; Rostaing Lionel

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Tocilizumab added to conventional therapy reverses both the cytokine profile and CD8+Granzyme+ T-cells/NK cells expansion in refractory hemophagocytic lymphohistiocytosis

机译：常规治疗中添加的Tocilizumab逆转了难治性吞噬淋巴细胞组织细胞增生症的细胞因子谱和CD8 +粒酶+ T细胞/ NK细胞扩增

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来源
《Hematological oncology》 |2016年第1期|共3页
作者
Faguer Stanislas; Vergez Francois; Peres Michael; Ferrandiz Ines; Casemayou Audrey; Belliere Julie; Cointault Olivier; Lavayssiere Laurence; Nogier Marie-Beatrice; Prevot Gregoire; Huart Antoine; Recher Christian; Rostaing Lionel;
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正文语种 eng
中图分类肿瘤学;
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1. Tocilizumab added to conventional therapy reverses both the cytokine profile and CD8+Granzyme+ T-cells/NK cells expansion in refractory hemophagocytic lymphohistiocytosis [J] . Faguer Stanislas, Vergez Francois, Peres Michael, Hematological oncology . 2016,第1期

机译：常规治疗中添加的Tocilizumab逆转了难治性吞噬淋巴细胞组织细胞增生症的细胞因子谱和CD8 +粒酶+ T细胞/ NK细胞扩增
2. PHARMACOKINETICS AND PHARMACODYNAMICS OF TOCILIZUMAB FOR THE MANAGEMENT OF CYTOKINE RELEASE SYNDROME (CRS) IN PEDIATRIC AND YOUNG-ADULT PATIENTS WITH RELAPSED/REFRACTORY (R/R) B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALL) TREATED WITH CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELL THERAPY TISAGENLECLEUCEL (CTL019) [J] . Awasthi Rakesh, Lee Clarice, Bittencourt Henrique, Pediatric blood & cancer . 2018,第Suppla1期

机译：用嵌合抗原受体（CAR）处理的小儿科和年轻成年患者细胞囊释放综合征（CRS）对小儿科和年轻成年患者进行细胞因子释放综合征（CRS）的药效学和药效学（CRS）（B-全部） T细胞疗法Tisagenlecleucel（CTL019）
3. Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice [J] . Satoshi Yoshihara, Yuying Li, Jinxing Xia, Frontiers in Immunology . 2019,第1期

机译：髓样细胞因子驱动的移植后吞噬淋巴细胞淋巴细胞增多以及人源化小鼠中T细胞和巨噬细胞活化的恶性循环
4. A NOVEL SCALABLE MANUFACTURING PLATFORM FOR T-CELL ACTIVATION AND EXPANSION IN ADOPTIVE T-CELL THERAPY [C] . Jian Ling Conference on advancing manufacture of cell and gene therapies . 2019

机译：适应性T细胞治疗中T细胞活化和扩展的新型可扩展制造平台
5. Tumor Infiltrating Lymphocyte Therapy for Renal Cell Carcinoma: Methods for ex vivo Expansion and T-Cell Memory Induction [D] . Braun, Mitchell W. 2021

机译：肾细胞癌患者肿瘤浸润淋巴细胞治疗：用于脱型膨胀和T细胞记忆诱导的方法
6. Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice [O] . Satoshi Yoshihara, Yuying Li, Jinxing Xia, -1

机译：骨髓细胞因子驱动的移植后吞噬淋巴细胞淋巴细胞增多和人源化小鼠中T细胞和巨噬细胞活化的恶性循环
7. Posttransplant Hemophagocytic Lymphohistiocytosis Driven by Myeloid Cytokines and Vicious Cycles of T-Cell and Macrophage Activation in Humanized Mice [O] . Satoshi Yoshihara, Yuying Li, Jinxing Xia, 2019

机译：骨髓细胞因子和T细胞的恶性循环驱动的后翻血血小毒淋巴管症和人源化小鼠的巨噬细胞激活

Tocilizumab added to conventional therapy reverses both the cytokine profile and CD8+Granzyme+ T-cells/NK cells expansion in refractory hemophagocytic lymphohistiocytosis

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