Synthesis and antibacterial activity of N-(2-(5-bromothiophen-2-yl)-2-oxoethyl) and N-((2-5-bromothiophen-2-yl)-2-oximinoethyl) derivatives of piperazinyl quinolones.

摘要

A series of N-[2-(5-bromothiophen-2-yl)-2-oxoethyl] and N-[2-(5-bromothiophen-2-yl)-2-oximinoethyl]derivatives of piperazinyl quinolones were synthesized and evaluated for antimicrobial activity against Gram-positive and Gram-negative microorganisms. Some of these derivatives exhibit comparable or better activity against Gram-positive bacteria, Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis, than ciprofloxacin, norfloxacin and enoxacine as reference drugs.