Fluorous 'Racemic' mixture synthesis: Polysaccharide-based chiral columns for simultaneous demix and enantioseparation of racemic fluorous tagged compounds

摘要

The proof of concept experiments of fluorous "racemic" mixture synthesis (FRMS) is shown using polysaccharide-based chiral stationary phases. The mixture of racemic O-benzoylmandelate derivatives bearing different lengths of fluorous cleavable tags undergoes sequential reactions to provide individual derivatives as well as their enantiomers resolved on polysaccharide-based chiral HPLC columns (DAICEL CHIRALCEL (R) and CHIRALPAK (R) series).