The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-HI): a research program striving to improve blood donor and transfusion recipient outcomes

摘要

BACKGROUND: The Recipient Epidemiology and Donor Evaluation Study-Ill (REDS-III) is a 7-year multi-center transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute. STUDY DESIGN AND METHODS: The domestic component involves four blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct programs in Brazil, China, and South Africa, which involve US and in-country investigators.RESULTS: REDS-III is using two major methods to address key research priorities in blood banking and transfusion medicine. First, there will be numerous analyses of large "core" databases; the international programs have each constructed a donor and donation database while the domestic program has established a detailed research database that links data from blood donors and their donations, the components made from these donations, and data extracts from the electronic medical records of the recipients of these components.