Response to the comment on Viberg et al. (200S) 'Neonatal ketamine exposure results in changes in biochemical substrates of neuronal growth and synaptogenesis, and alters adult behavior irreversibly' by Ching-Hung Hsu

摘要

The present topic has recently been up for debate in scientific journals (Eriksson, 2008a,b; Hardy and Stedeford, 200Sa,b), all which apply the peer-review process, the quality assurance of the scientific community. During the past 20 years more than a 100 reviewers and statistical experts, as part of the peer-review process, have accepted the experimental design and evaluation'of our data, leading to publication of more than 60 articles in scientific journals. What can be concluded is that there is a difference of opinions concerning what statistical evaluation should be used when directly dosing the newborn pups from a litter during the neonatal period, in contrast to dosing the dam in order to indirectly expose the offspring in utero and/or during the lactation period.