Quantification of Lamotrigine in Patient Plasma Using a Fast Liquid Chromatography-Tandem Mass Spectrometry Method With Backflush Technology

摘要

Background: Recent concerns have been raised by neurologists and patients with epilepsy regarding the bioequivalence of generic lamotrigine to the brand Lamictal. Bioequivalence studies require the quantification of lamotrigine in human plasma, including in the presence of other drugs, for studies that will use patients with epilepsy rather than healthy volunteers.