Clinical outcomes of pandemic (H1N1) 2009 influenza (swine flu) in adults with cystic fibrosis.

摘要

Patients with cystic fibrosis (CF) suffer recurrent bacterial pulmonary infections, but viral infections can also cause acute clinical deterioration. Certain patient groups suffer increased morbidity following pandemic (H1N1) 2009 influenza (swine flu), but there are few previous reports of outcomes in individuals with CF. The West Midlands, along with Greater London, has had the highest incidence of H1N1 influenza in the UK.5 We therefore examined the outcomes of patients diagnosed with H1N1 influenza at the West Midlands Adult CF Centre. From June 2009 to April 2010 all adults with CF at our regional centre with potential H1N1 influenza had nasopharyngeal swabs tested by PCR. PCR testing was instituted in patients with fever >38degC together with one or more of the following: sore throat, rhinorrhoea, loose bowel motions, myalgia and headache. We documented clinical management, as well as lung function and body mass index (BMI) at the visit prior to their febrile illness and at their subsequent clinic visit. We used paired and unpaired Student t test and Mann-Whitney U test as indicated.